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'Allergic-like'? reaction risk in patients undergoing non-intravenous contrast urography
Section of Urology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
Dec  2018 (Vol.  25, Issue  6, Pages( 9601 - 9605)
PMID: 30553286


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    Though widely performed, the safety of non-intravenous contrast (NIVC) urography in patients with documented intravenous, iodinated contrast allergic like reactions (ICA) is unclear. The purpose of this study was to determine the risk of 'allergic-like' reaction (ALR) events in patients with ICA undergoing NIVC urography.


    Patients undergoing contrast urography at a single institution were identified between 2011-2014. Patient charts were reviewed for documented ICA prior to index surgery, preoperative allergy prophylaxis with steroid or antihistamine, and acute allergic reactions identified by ICD codes within 24 hours of surgery.


    A total of 2,650 patients were included, 1,325 female (50%). Of these patients, 113 (4.2%) had an ICA. Overall 33% (37/113) of patient received preoperative allergy prophylaxis with a steroid or antihistamine. A potential ALR related ICD-9 code was identified in one patient (0.8%) with a prior IVC ALR without allergy prophylaxis within 24 hours preoperatively undergoing percutaneous nephrolithotomy (PCNL). This event was found to be an associated with a myocardial infarction and lacked ALR sequelae.


    Despite commonly voiced concerns, in this large series of over 2,500 patients, including 113 patients with a prior history of ICA undergoing contrast urography, only one patient was found to have a potential ALR event following PCNL. No patients undergoing a retrograde contrast urography with prior, documented ICA had a NIVC ALR event despite a low rate of pretreatment with corticosteroid or antihistamine.