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Hypofractionated radiotherapy with concomitant sunitinib - is there a radiosensitizing effect?
Department of Radiation Oncology, CRCHUM-Centre Hospitalier de l?Universit? de Montr?al ? H?pital Notre-Dame, Montreal, Quebec, Cana
Apr  2009 (Vol.  16, Issue  2, Pages( 4599 - 4600)
PMID: 19364436


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  • We present a case of a patient with metastatic renal cell cancer (RCC) treated with hypofractionated radiotherapy while being treated with sunitinib. He received a single dose of 8 Gy of external beam radiation to a metastatic mass of several centimeters diameter in the right lateral ribs, followed by a second identical dose. Clinically, the patient achieved a nearly complete disappearance of the mass. We discuss the possible synergy between tyrosine kinase receptor inhibitors (TKRIs) and radiotherapy and the importance of dose fractionation.