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Phenotype symptom severity and treatment in a cured cohort of chronic pelvic pain syndrome patients
Cleveland Clinic Glickman Urological and Kidney Institute, Cleveland, Ohio, USA
Feb 2015 (Vol. 22, Issue 1, Pages( 7623 - 7626)
PMID: 25694009

Abstract

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  • INTRODUCTION:

    To identify a cohort of chronic pelvic pain syndrome (CPPS) patients who considered their symptoms completely resolved and analyze their demographics, clinical phenotype, treatments and NIH-Chronic Prostatitis Symptom Index (CPSI) scores.

    MATERIALS AND METHODS:

    We identified 35 CPPS patients who at the follow up, reported their symptoms completely resolved ('cured'). Demographics, UPOINT phenotypes, treatments, and CPSI scores were examined. We also compared these variables to a database of 220 previously evaluated CPPS patients.

    RESULTS:

    Patients ranged in age from 19 to 72 years. Median follow up was 12 months. Mean change in CPSI sub scores before and after therapy were pain 9.7 +- 3.8 to 2.7 +- 2.9, urinary 4.0 +- 2.8 to 1.1 +- 1.2, QoL 8.1 +- 2.7 to 2.3 +- 2.5, and total 21.8 +- 6.6 to 6.2 +- 1.0 (all p < 0.0001). Only 9 (26%) patients reported a total score of 0. Comparing this 'cured' group to a previously published cohort of phenotyped CPPS patients, the 'cured' group had lower starting total and pain CPSI scores (21.8 versus 25.0 p = 0.007; 9.7 versus 11.5 p = 0.006 respectively).

    CONCLUSIONS:

    Many men with CPPS can reach a subjective cure, however, the majority do not reach a CPSI score of 0. This group of 'cured' patients is similar to our typical tertiary referral cohort in terms of age and phenotype but differs in having slightly lower pre-treatment CPSI scores.

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