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Clear cell renal cell carcinoma with osseous metaplasia: a case report
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Feb  2011 (Vol.  18, Issue  1, Pages( 5564 - 5567)
PMID: 21333055

Abstract

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  • INTRODUCTION:

    Osseous metaplasia is a rare histologic feature not often associated with renal cell carcinoma; there are only 14 reported cases and just four associated with the clear cell variant. We report the case of a 48-year-old female who presented with diffuse abdominal pain.

    MATERIALS AND METHODS:

    We reviewed the case of woman who underwent a robotic assisted partial nephrectomy for an enhancing renal mass. Histologic analyses and immunostains were reviewed by multiple pathologists.

    RESULTS:

    CT imaging revealed a 1.8 cm irregular enhancing exophytic mass with calcifications. The patient subsequently underwent robotic assisted laparoscopic partial nephrectomy. The final pathologic diagnosis was clear cell carcinoma with metaplastic bone formation.

    CONCLUSION:

    While the prognostic significance of bone metaplasia occurrence in renal cell carcinoma is controversial, such that can safely be managed with partial nephrectomy.